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The most powerful acne medications are typically prescription-strength and may vary depending on the severity and type of acne. If you are looking for some genuine cure then must  try accutane 40 mg
Here are some of the most effective ones:
Topical treatments:

1. Retinoids (e.g., adapalene, tretinoin): Derivatives of vitamin A that prevent clogged pores and reduce inflammation.
   
2. Benzoyl peroxide (e.g., Epiduo): Kills P. acnes bacteria and unclogs pores.
   
3. Sulfacetamide (e.g., Sulfacet-R): Antibacterial and anti-inflammatory properties.
   

Oral antibiotics:

1. Doxycycline: Targets P. acnes bacteria and reduces inflammation.
   
2. Minocycline: Similar to doxycycline, with broader antibiotic coverage.
   

Hormonal treatments:

1. Spironolactone (e.g., Aldactone): Blocks androgen hormones that contribute to acne.
   
2. Birth control pills (e.g., Yaz, Ortho Tri-Cyclen): Regulate hormones and reduce acne.
   

Isotretinoin (e.g., Accutane): An oral retinoid for severe, resistant acne. It's usually reserved for extreme cases due to potential side effects.
Remember: These powerful medications should only be used under the guidance of a dermatologist or healthcare professional. They may have side effects, and it's essential to discuss the risks and benefits before starting treatment.